Diagnosis of Diffuse Pontine Gliomas
| Diffuse pontine gliomas are located in the brainstem, at the base of the brain. They are usually diagnosed in children aged 5 to 10. They are difficult to treat because the tumor cells grow in between and around normal cells. It is impossible to remove a tumor in this area because it interferes with the functioning of this critical area of the brain.
Signs and Tests.
How do you know that a child has a diffuse pontine glioma?
| Doctors and other medical professionals will use well-established diagnostic tests to see if a brain tumor is causing your child’s symptoms. These tests will include a physical examination, and brain scans such as magnetic resonance imaging (MRI). The diagnosis is usually made based on the signs and symptoms in your child, and on the results of the MRI study. When the tumor can be identified on the MRI, a biopsy is not necessary.
Treatment of DIPG.
The standard treatment for DIPG is 6 weeks of radiation which often dramatically improves symptoms. Unfortunately, problems usually recur after 6 to 9 months, and progress rapidly.
(Source: St Jude Childrens Research Hospital)
Treatment of Diffuse Pontine Gliomas
| How is a diffuse pontine glioma treated? >
These tumors are treated with radiation therapy, which are high-energy X-rays that destroy tumor cells. This treatment can reduce symptoms significantly, but there may be some permanent damage caused by the tumor which can’t be helped. Steroids, another type of drug, are often given to improve some of the symptoms. Surgery is not part of the standard treatment because the tumor has grown within a part of the brain where resection is impossible. The effectiveness of chemotherapy is still uncertain.
more on Treatments
Diffuse Intrinsic Pontine Gliomas are difficult to treat because the tumor cells grow in between and around normal cells. It is impossible to remove a tumor in this area because it interferes with the functioning of this critical area of the brain.
Radiation (30 sessions done under general anestethia) is the only proven existing treatment for DIPG and produces a temporary improvement in symptoms (average of 3 months) which eventually reappear and develop at a much faster, more aggressive pace.
While the search for a cure continues, children with DIPG must endure one experimental trial after another, usually suffering terrible side-effects. Ultimately, it is with enormous cruelty that this disease takes its final toll. DIPG spares children of their cognitive abilities, allowing them to remain fully aware of their decline, while robbing them of their motor functions resulting in partial paralysis, loss of voice, sight and finally their ability to eat and breathe.
Treatment of recurrent diffuse intrinsic pontine glioma
Treatment of recurrent diffuse intrinsic pontine glioma
Journal of Neuro-Oncology, 08/26/2011
Wolff JE et al. – Repeat radiation resulted in the highest response rates (4/7), and the longest progression–free survival. These data provide a basis to plan future clinical trials for recurrent diffuse intrinsic pontine gliomas(DIPG). Repeat radiation therapy should be tested in a prospective clinical study.
Retrospective chart review of patients with recurrent DIPG treated between 1998 and 2010 was conducted.
Response progression–free survival and possible influencing factors were evaluated.
31 patients were identified who were treated in 61 treatment attempts using 26 treatment elements in 31 different regimens.
Most frequently used drugs were etoposide (14), bevacizumab (13), irinotecan (13), nimotuzumab (13), and valproic acid (13).
7 patients had repeat radiation therapy to the primary tumor.
Response was recorded after 58 treatment attempts and was comprised of 0 treatment attempts with complete responses, 7 with partial responses, 20 with stable diseases, and 31 with progressive diseases
Median progression–free survival after treatment start was 0.16 years (2 months) and was found to be correlated to the prior time to progression but not to the number of previous treatment attempts.
Medical Marijuana helps relieve many symptoms associated with DIPG -anxiety, aggression, panic disorders, generalized rage, tantrums, property destruction, and self-injury behavior.
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Expectations (prognosis) for Diffuse Intrinsic Pontine Gliomas (DIPG).
What is the outcome for a child with a diffuse pontine glioma?
| Because they are difficult to treat, the outcome for brainstem gliomas is poor. After diagnosis, the survival time is on average 9 to 12 months. To improve the outcome, doctors have tried giving higher amounts of radiation, or using chemotherapy medicines to kill the tumor cells. Research is underway to achieve better results. When the tumor recurs, the focus of treatment is on managing symptoms to make sure the child is as comfortable as possible.
Complications of Diffuse Intrinsic Pontine Gliomas (DIPG).
Complications of Cannabis (marijuana).
Marijuana Toxicity - Mar Vista Animal Medical Center | (BIZ)
Jan 26, 2011 ... Diffuse Intrinsic Pontine Gliomas (DIPG) ? Cat Neonatal Isoerythrolysis ... done with humans can be done in dogs to make the diagnosis of marijuana intoxication. ...
Marijuana, known by many names, needs very little introduction; we all know it is a popular recreational drug smoked illegally by millions of people worldwide. Its psychoactive ingredient is delta 9-tetrahydrocannabinol, more commonly called “THC.” Regular marijuana is typically 1-8% THC while hashish, made from the flowering tops of the plant and their resins, can contain up to 10% THC. Other properties of
THC give it controversial medicinal properties: appetite stimulation and nausea control.
Visit - http://www.marvistavet.com/html/body_marijuana_toxicity.html -
WHAT YOU NEED TO KNOW
TO UNDERSTAND THIS DISEASE ...
DIPG is a disease which interrupts the way nerves communicate with muscles. In order to understand this disease, you must have some understanding of how things work in the normal situation.
Visit - http://www.marvistavet.com/html/body_myasthenia_gravis.html - for more.
Calling your health care provider.
Support Groups for Diffuse Intrinsic Pontine Gliomas (DIPG)
The stress of illness can often be helped by joining support groups where members share common experiences and problems.
Organizations can provide additional information and help on Diffuse Intrinsic Pontine Gliomas (DIPG), see DIPG resources.
See DIPG -> support groups, et al.
Calling your health care provider
Call your health care provider with any concerns about DIPG or if you think that your child is not developing normally.
or side effects from medication - such as
recurrent thoughts, irritability, and problems with sleep.
Go to the emergency room or call the local emergency number (such as 911) if you have breathing difficulty or swallowing problems.
Prevention of Diffuse Intrinsic Pontine Gliomas (DIPG)? |
See Causes and Risk Factors.
more SOURCEs & LINKs:
Glioma Definition. Crossword Dictionary. - Crosswords911.com
Diffuse Intrinsic Pontine Glioma (DIPG) :: ... Glioma Research and Marijuana Glioma Research ... Paul has collected the latest research on medical Cannabis, ...
The Society for Neuroscience is a nonprofit membership organization of basic scientists and physicians who study the brain and But now an understanding of the biological makeup and survival mechanisms of glioma tumors is helping researchers develop methods that they hope will kill the cancer. — “Society for Neuroscience - Glioma Brain Tumors”, Glioma definition, a tumor of the brain composed of neuroglia. See more. — “Glioma | Define Glioma at ”, A brain glioma can cause headaches, nausea and vomiting, seizures, and cranial nerve disorders as a result of increased intracranial pressure. "To date, improvements in overall survival for newly diagnosed glioma patients have been negligible," said Andrew T. Parsa, MD, PhD, associate. — “Glioma - RM Global Health WiKi”,
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Cannabis and Diffuse Intrinsic Pontine Gliomas (DIPG) - 420 Magazine ®
ASA : Medical Marijuana
Pages tagged "DIPG"
Someday I’ll be done asking how this happened. Someday I’ll be done
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Patient Testimonials | MediCann
is interested in knowing how medical cannabis has helped you. ... >
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Erowid Experience Vaults: Cannabis - Diffuse Intrinsic Pontine Gliomas (DIPG)
Visit - http://www.erowid.org/experiences/exp.cgi?S1=0&S2=-1&C1=-1&Str=DIPG
Medical Marijuana Nephritis Treatments | Cannabis Symptom Relief
Medical Marijuana helps relieve many symptoms associated with Diffuse Intrinsic Pontine Gliomas (DIPG) - anxiety, aggression, panic disorders, generalized rage, tantrums, property destruction, and self-injury behavior.
Visit - http://medicalmarijuana.com/medical-marijuana-treatments/DIPG
Marijuana: 1276 user reviews - DailyStrength | (INF)
Treatment Success Rates ...
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Condition, Members, Success -
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RxMarihuana.com: Index of Medical Conditions | (INF)
Marijuana: The Forbidden Medicine. Index of Medical Conditions Addressed ...
Diffuse Intrinsic Pontine Gliomas (DIPG)
... and more.
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Tetrahydrocannabinol - Wikipedia, the free encyclopedia | (INF)
Tetrahydrocannabinol (THC), also known as delta-9-tetrahydrocannabinol (Delta9-THC, Delta1-THC (using an older chemical nomenclature), or dronabinol, is the main psychoactive substance found in the cannabis plant.
... Two studies indicate that THC also has an anticholinesterase action which may implicate it as a potential treatment for Alzheimer's and Diffuse Intrinsic Pontine Gliomas (DIPG).
Visit - http://en.wikipedia.org/wiki/Tetrahydrocannabinol - for more.
Reflections Of Grace Foundation | Formally established in late December 2008, the Reflections Of Grace Foundation is the result of nearly a year of deliberation, discussion and planning. After the death of their five year old daughter Grace Elizabeth on Valentine’s Day 2008 to a particularly virulent form of brain cancer, co-founders Tamara and Brian Ekis decided to channel their grief in a positive way by establishing an organization devoted to making a difference. The foundations’s name, Reflections Of Grace, signifies the effect their daughter had on the lives of those she touched over the course of her short life.
The Cure Starts Now | strives to generate the resources necessary for doctors to study DIPG and implement the findings in hope of curing DIPG, and hopefully all cancers.
Riah's Rainbow | The ultimate goal of Riah's Rainbow is to bring smiles to the faces of children who have to endure a day, a week or even months in the hospital. Our mission is to be able to give pediatric patients at local hospitals new coloring books, crayons, markers, colored pencils, craft items, etc. Each time they visit they will receive a new coloring book & box of crayons to take home with them.
Raising awareness of all types of pediatric brain tumors, with a particular focus on Diffuse Intrinsic Pontine Gliomas (DIPG), is one of the most valuable gifts we can give our children who fought so hard. We will also be joining other like-minded organizations in funding the search for a cure for DIPG and other forms of pediatric brain cancer, in the hope of curing all cancers.
Lyla Nsouli Foundation | This Foundation was set up to improve the prognosis of children with DIPG and eventually find a cure for this terrible form of brain cancer.
They fund children's brain cancer research projects which have the highest chance to quickly have a significant impact on children with DIPG.
Facts re medical marijuana (Cannabis) as medicine, laws for medicinal marijuana, patient resources, recipes.
Featured Medical Marijuana Patient Accounts
We are most interested in continuing to share website visitors' medical marijuana histories to provide insight into uses for this medicine which are not widely known.
If you wish to send us a personal account of your medical marijuana experiences, check our submission guidelines and use the RxMarijuana Information Exchange form.
Visit - http://rxmarijuana.com/shared.htm
see more Forums > here <
Medicinal Marijuana Uses | (ORG)
... Sclerosis - Muscle Spasm - Diffuse Intrinsic Pontine Gliomas (DIPG) - Myofascial Pain Syndrome ... Who approves of Medical Marijuana -. While the prohibition of cannabis is ...
to Contact: visit - http://alluseismedicinal.org/Medicinal_Marijuana_Uses.html
Helping Doctors Helping Marijuana Patients and Caregivers | (ORG) Legal Users Guide to the Michigan Medical Marijuana Act; a Resource for Legal and Medical Professionals Qualifying Patients and CareGivers ...
HELP FOR PHYSICIANS HELP FOR PATIENTS HELP FOR CAREGIVERS HELP FOR LAWYERS LAW & AGENCY RULES FORMS BANK SCHMID LAW
Make a General Inquiry: Ask Here
... Menstrual Bleeding), Migraine, general Muscle Spasm, DIPG ...
to Contact: visit - http://qualifyingpatient.com/
California Cannabis Research Medical Group (CCRMG).
* (ORG, inf) Winter/Spring 2005 - O'Shaughnessy's; Journal of the California Cannabis Research Medical Group. Letter from a Soldier - “Is Cannabis Recommended for Diffuse Intrinsic Pontine Gliomas (DIPG)?” - “Hello Dr. Mikuriya, I have recently returned home from Iraq. This was my second tour. I only had about 4 months between the two tours. I … am at a high state of alertness and I startle at certain noises. My tolerance is also very low, I get angry very easily. Not violent, I still have control but very agitated. I also have trouble sleeping and sometimes I have to take a sleeping pill or Nyquil to go to sleep. I went to my doctors and they sent me to a place on base that helps with DIPG.” … Cannabis would indeed be useful in managing symptoms of Autism. This has been known for over a century in the medical profession but forgotten because of its ... visit: www.ccrmg.org/journal/05spr/opinion.html
Boston Children's Hospital |
Children with diffuse intrinsic pontine glioma (DIPG) are treated through the Glioma Program at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, ...
Treatment & Care
Research & Clinical Trials
The Weill Cornell Brain and Spine Center serves as one of the country's premier providers of minimally invasive surgery for the brain and spine in adults and children.
A leader in high-tech computerized diagnostic and treatment methods, the Weill Cornell Brain and Spine Center receives patients from around the world. Our specialists treat the full spectrum of neurological disease, from brain and spine tumors, stroke, aneurysms, and epilepsy to Parkinson's disease and other movement disorders.
Cannabis and Diffuse Intrinsic Pontine Gliomas (DIPG) - A Partnership for the Better?
>> Visit -
CANNABIS CURES CANCERS! | Facebook
... with cannabis oil. At the time marijuana was not ... with diffuse intrinsic pontine glioma, or DIPG, ... Oregon Medical Marijuana Program. The oil ...
>> Visit -
Hail Mary Jane (HMJ) is one of the premier Cannabis Culture blogs on the Internet. We believe that stoners can be productive and live happy, fulfilling lives, while still contributing to society in a meaningful way. Our goal is to set a model for cannabis users to look up to in our actions as well as our consistency and to inform them about various new products, innovations, events, and services available in the cannabis industry.
We are a resource that provides unbiased political and health information regarding cannabis and all the aspects of the cannabis consumer lifestyle, including but not limited to entertainment, culture and fashion. We believe in personal rights and freedoms and that all adults should have the right to make their own decisions about how to relax. Stay lifted.
>> Visit -
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will be listed here as we learn about them. Got one? Post It! and let everybody know ...
Cure Your Cancer with Cannabis Oil
| ... a friend began to forward me information on marijuana/cannabis oil ... diffuse intrinsic pontine glioma, or DIPG, ... Cannabis Research Medical ...
>> Visit -
A dose of HOPE - Pamplin Media Group
Cannabis community comes together to help girl, 4, fight rare cancer
On a recent sunny day, sisters Leah, 4, and Nora Merklin, 2, were awarded membership into a special club: the Mix ‘n’ Match Creamery Forever Club. What this means is that both girls will get free ice cream forever, said Eric West, owner of the Oak Grove ice cream shop.
When West opened his shop on April 16, he started with a “goal to bring joy to people within the community and internationally,” by pledging a percentage of his profits to help children in need.
When his friend Jody Schreffler, an Oak Grove resident, told him about Leah being diagnosed with diffuse intrinsic pontine glioma, or DIPG, he realized he had an opportunity to help a family practically in his shop’s backyard.
“I’m honored to have an opportunity to make the girls and their parents more joyful,” West said.
“Our doctor told us that chemo and radiation will not cure DIPG, so we had decided on no treatment at all, until God threw something in our laps,” she added.
That something was cannabis oil, and it has made a dramatic difference in Leah’s condition.
Cannabis and cancer
| Merklin and her husband, Erik, obtain the cannabis oil legally through the Oregon Medical Marijuana Program. The oil must be ingested, so they sandwich it between Cheerios and Leah eats the substance three times a day.
The side effects?
“She is hungry and she sleeps better,” Merklin said, noting that those are both good things.
When Leah was first diagnosed, she was given from six months to a year to live, so her parents made sure she received her Make-A-Wish trip to Disneyland right away.
When they came home from California, they found out about cannabis oil from a group of parents on Facebook, and soon everywhere they looked, they found research about the oil helping with DIPG.
“The cannabis oil causes cancer cells to die in a cleaner way,” Merklin said.
Before the oil treatments, “Leah couldn’t walk without falling, and her eyes crossed. Now, she is able to go to school without me, she can walk, and some days her eyes are not crossed,” Merklin said.
“She has passed her one-year mark and her MRI in January showed that the tumor’s growth was minuscule,” she said.
>> SOURCE >>
SCHERR v. CITY OF CHICAGO - FindLaw
United States Court of Appeals,Seventh Circuit.
Jennifer SCHERR, Plaintiff–Appellant, v. CITY OF CHICAGO, et al., Defendants–Appellees.
Decided: July 2, 2014
The plaintiff (whom we'll call Jennifer, because the principal defendant has the same last name) sued two Chicago police officers, plus the City itself, primarily seeking damages for their having (she alleged) violated her Fourth Amendment rights—the officers by including deliberate falsehoods in their affidavit supporting their request for the issuance of a search warrant and the City by failing to give the officers the training required to prevent their irresponsible behavior.
In February 2011, Jennifer's then seven-year-old daughter, Liza, had been diagnosed with a rare brain tumor called Diffuse Intrinsic Pontine Glioma. This tumor forms in an area of the brainstem, called the pons, that controls many basic bodily functions, such as breathing. The disease is almost always fatal, usually within months of being diagnosed. See Dana–Farber/Boston Children's Cancer and Blood Disorders Center, “Diffuse Intrinsic Pontine Glioma (DIPG) Overview,” www.danafarberbostonchildrens.org/Conditions/ Brain–Tumor/Diffuse–pontine–glioma.aspx (visited on July 2, 2014); Katherine E. Warren, “Diffuse Intrinsic Pontine Glioma: Poised for Progress,” 2:205 Frontiers in Oncology (2012). In 2012, Jennifer learned that oil derived from marijuana plants (called “cannabis oil” or “marijuana oil”) might, if fed to her daughter, provide therapeutic benefits; some medical evidence supports this belief. See, e.g., Rick Doblin et al., “Marijuana as Antiemetic Medicine: a Survey of Oncologists' Experiences and Attitudes,” 9 J. Clinical Oncology 1314 (1991).
The legal status in Illinois of cannabis oil was unclear in 2012, but Jennifer was able to buy it, and did. But it was expensive and Jennifer decided to switch to growing her own marijuana and extracting the oil from it for her daughter. She was assisted in this endeavor by her father-in-law, Curtis Scherr (whom we'll call Curtis for the same reason we're calling the plaintiff Jennifer), a Chicago police officer. Although advising her of the legal risks of growing the plants, Curtis helped her grow them by supplying her with the specialized light bulbs required for growing the plants indoors. And he would stop by Jennifer's home from time to time to “check on the crop.”
Liza died on July 10, 2012. The funeral was held on the fifteenth. In the days immediately before and after the funeral, a bitter conflict erupted between father-in-law and daughter-in-law. The complaint alleges (and because it was dismissed on the pleadings we take the allegations to be true, of course without vouching for their truth) that
upon Liza's passing, Jennie [Jennifer Scherr] elected to allow Liza's body to remain at the family residence in Evergreen Park for a certain amount of time so that Jennie and the family, including Liza's three younger siblings (5 years and 3 year old twins) could pay respect and grieve in a manner Jennie thought appropriate. Defendant Officer Scherr objected to the body remaining at the residence and caused conflict within the family when Jennie asserted her wish to do so.
On either the second or the third day after the funeral, Curtis, together with a fellow police officer, codefendant Ruben Briones (an officer assigned to the police department's Narcotics Division), prepared an affidavit in support of an application to a state court for a warrant to search Jennifer's house for illegal drugs. The affidavit, based entirely on information supplied by Curtis, stated that on the sixteenth (the day after the funeral) he had observed 50 marijuana plants in Jennifer's basement. Although her last name and his last name—which are identical—are in the affidavit, the affidavit contains no other indication of a relationship between them.
A Cook County judge approved the application for a search warrant and issued the warrant on June 19, and on the same day (which remember was only the fourth day after the funeral), between twelve and fifteen DEA officers descended on Jennifer's home to search for marijuana. They found none. She is not a dealer or an addict and so had discarded the marijuana plants upon her daughter's death. She was not arrested and no criminal proceedings were brought against her. Instead she brought this suit against the two officers and the City.
Curtis's behavior, which culminated in the DEA's search of his daughter-in-law's house, was, if it was as the complaint describes it, atrocious. And if he knew, when he submitted it in support of the application for a search warrant, that there was no longer any marijuana in his daughter-in-law's house, the issuance of the search warrant was based on a knowingly false assertion of probable cause for the search, and Jennifer's Fourth Amendment rights were violated under the principle of Franks v. Delaware, 438 U.S. 154 (1978). But there is no allegation that when the warrant was applied for he knew she'd discarded the marijuana plants. And at the time there was no medicinal exception in Illinois to the prohibition of possessing marijuana, as there is now, 410 ILCS 130/1 et seq. Moreover, there was and still is no medicinal exception to the federal law against possession of marijuana (even simple possession, with no intent to distribute), 21 U.S.C. § 844, and the fact that the search was conducted by DEA agents suggests a possible federal interest in Jennifer's marijuana plants. The affidavit states that Curtis saw the plants in Jennifer's basement three days before he signed the affidavit, and as far as we know that is true.
The affidavit was nevertheless misleadingly incomplete. For Curtis was concealing from the judge asked to issue the search warrant information that if disclosed in the affidavit might well have doomed the application. Had the affidavit stated that the suspected possessor of the 50 marijuana plants was the affiant's own daughter-in-law, the judge would almost certainly have asked Curtis what was going on that would induce him to accuse his own daughter-in-law of criminal behavior, and upon learning the details the judge probably would have told Curtis to “work things out” privately—that this wasn't a proper matter for a criminal proceeding.
But candor in the affidavit would not have undermined the existence of probable cause. Curtis had, so far as appears, seen marijuana plants in Jennifer's basement just a few days earlier. Her possession of them had been criminal even if she'd been planning to get rid of the plants and just hadn't gotten around to doing so yet (though in fact she had). What was wrong with the affidavit was the motivation—Curtis's spite, his desire to see his daughter-in-law arrested just four days after the death of her child (his grandchild) and maybe even prosecuted (though that would be an unlikely sequel to the search even if the plants had still been in her basement)—though if she were prosecuted he might be as well, as her accomplice in the growing of the marijuana.
A “yes” would be far less plausible if a criminal asked that he be allowed to go free because the constable, though he had committed no legal error, had been impelled by nasty, spiteful thoughts unbecoming in a law enforcement officer.
All this said, the State of Illinois might be wise to require slightly more information in affidavits in support of warrant applications—information about the existence of a family or business relationship between the affiant (usually either a police officer, as in this case, or a prosecutor) and the person who is to be arrested or whose residence is to be searched. Such information would identify a conflict of interest that might make it prudent to reject the application. Such an inquiry would have been prudent here, as the likely upshot would have been no raid on Jennifer's home—and the time of the DEA agents would have been saved, the grieving mother spared further emotional distress, and this suit not brought.
We close with a brief discussion of two claims, other than the Fourth Amendment claim, that Jennifer Scherr might have pursued. One, which she included in her complaint but the district judge rejected and she has abandoned on appeal, was a claim of a “class of one” denial of equal protection. See, e.g., Village of Willowbrook v. Olech, 528 U.S. 562, 563–64 (2000) (per curiam); Del Marcelle v. Brown County Corp., 680 F.3d 887 (7th Cir.2012) (en banc); Hilton v. City of Wheeling, 209 F.3d 1005, 1007–08 (7th Cir.2000). The limits of the doctrine are unclear, as is plain from our en banc decision in the Del Marcelle case, with its three opinions, none commanding a majority of the judges. But the opinion in the Hilton case states that a “class of one” denial of equal protection can be proved by evidence “that the defendant deliberately sought to deprive [the plaintiff] of the equal protection of the laws for reasons of a personal nature unrelated to the duties of the defendant's position.” Id. at 1008. That sounds very much like a description of Officer Scherr's behavior toward his daughter-in-law in this case.
>> SOURCE >>
Diffuse intrinsic pontine glioma: poised for progress
PRESENTATION AND DIAGNOSIS. Diffuse intrinsic pontine glioma is generally a disease of middle childhood, with the majority of children diagnosed between 5 ...
Diffuse intrinsic pontine gliomas (DIPGs) are amongst the most challenging tumors to treat. Surgery is not an option, the effects of radiation therapy are temporary, and no chemotherapeutic agent has demonstrated significant efficacy. Numerous clinical trials of new agents and novel therapeutic approaches have been performed over the course of several decades in efforts to improve the outcome of children with DIPG, yet without success. The diagnosis of DIPG is based on radiographic findings in the setting of a typical clinical presentation, and tissue is not routinely obtained as the standard of care. The paradigm for treating children with these tumors has been based on that for supratentorial high-grade gliomas in adults as the biology of these lesions were presumed to be similar. However, recent pivotal studies demonstrate that DIPGs appear to be their own entity. Simply identifying this fact releases a number of constraints and opens opportunities for biologic investigation of these lesions, setting the stage to move forward in identifying DIPG-specific treatments. This review will summarize the current state of knowledge of DIPG, discuss obstacles to therapy, and summarize results of recent biologic studies.
More than 70% of children with tumors of the central nervous system (CNS) will survive at least 5 years from diagnosis (Smith et al., 2010; Howlader et al., 2011). However, pediatric CNS tumors represent a heterogeneous group of diseases and the dismal survival of select tumor subtypes, such as diffuse intrinsic pontine gliomas (DIPG), is not reflected in this number. The median survival for children with DIPG is less than 1 year from diagnosis (Mandell et al., 1999; Cohen et al., 2011), and no improvement in survival has been realized in more than three decades. The reason for this stagnancy has, at least in part, been attributed to our lack of understanding of the biology of this disease.
DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) - National Center for ...
HYPOFRACTIONATED RADIOTHERAPY FOR PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): A PROSPECTIVE CONTROLLED RANDOMIZED TRIAL
BACKGROUND: Pediatric Diffuse intrinsic pediatric glioma (DIPG) remained dismal regardless of the new therapeutic and technical attempts. PURPOSE: To investigate the efficacy and toxicity of hypofractionated radiotherapy in pediatric DIPG compared to conventional radiotherapy and to determine the prognostic factors for its overall (OS) and progression-free survival (PFS). PATIENTS AND METHODS: Sixty four children, below the age of 18 years, who presented to Children's Cancer Hospital, Egypt (CCHE) during the period July 2007 and July 2011 were randomized into 2 groups. The hypofractionated group received 39 Gy in 13 fractions in 21/2 weeks and the conventional arm receiving 55.8 Gy in 31 fractions in 6 weeks using conformal radiotherapy technique. The two arms were not different in age, gender, performance status and tumor volume.
RESULTS: Thirty two children were randomized in each arm. The median OS for the whole group was 9.5 ± 1.0 months: 7.4 ± 1.0 months for the hypofractionated arm and 9.9 ± 1.0 months for the conventional arm. The whole group has median PFS of 7.3 ± 0.8 months; 7.0 ± 1.4 months for the hypofractionated and 7.7 ± 1.1 for the conventional arm. On the other hand, the 1-year and 2-year OS were 41.4 ± 9.2% and 28.4 ± 8,8% in the hypofractionated arm and 36.2 ± 8.7% and 32.3 ± 7.8% in the conventional arm. None of these differences was statistically significant. Furthermore, none of the tested factors (age, gender, performance status, tumor volume, radiation volume or tumor extension) proved to have statistically significant influence on OS or PFS. All patients showed marked degree of improvement in symptoms and signs with earlier response in the hypofractionated arm. The immediate and delayed side effects were not different between the 2 arms.
CONCLUSIONS: Hypofractionated radiotherapy had similar overall, progression-free survival and delayed effect (in the long survivors) to conventional fractionation. It offers less burden on the patients, their families and the treating machines and departments.
Resident runs to spread awareness about nonprofit
Santa Clarita resident Janet Demeter visited Boston, Mass., to promote awareness about Diffuse Intrinsic Pontine Glioma, or DIPG. Completing an awareness ...
Santa Clarita resident Janet Demeter visited Boston, Mass., to promote awareness about Diffuse Intrinsic Pontine Glioma, or DIPG.
Completing an awareness run, Demeter talked to people about the loss of her son to DIPG and her SCV nonprofit Jack’s Angels Foundation, named in his honor.
Each year, 80 percent of pediatric brain tumor deaths are caused by DIPG, and brain tumors are the No. 1 cause of cancer-related deaths in children, she said.
However, Demeter says DIPG is one of the least-funded areas of cancer research.
RxMarijuana.com | Marijuana: The Forbidden Medicine.
(ORG, inf, Book) Featured Medical Marijuana Patient Accounts * to share website visitors' medical marijuana histories to provide insight into uses for this medicine which are not widely known. … If you wish to send us a personal account of your medical marijuana experiences, ... Cannabis and DIPG by Michael McKenna ... visit: www.rxmarihuana.com/shared.htm
(web-ring / link-list) * Your starting point for the best medical info. Free Medical Cannabis info Find what you're looking for! Visit: www.medical-101.com/s/medical_cannabis
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